Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease

This review contains up-to-date information on the fundamentals and clinical aspects of white matter disease in chronic progressive cerebrovascular with cognitive impairment, leading risk factors for which are hypertension cerebral atherosclerosis. Highly informative methods neuroimaging have contributed significantly to study this problem, confirming important role changes development progression impairment. The full range morphological matter, typical vascular encephalopathy dysfunction, is presented. Chronic hypoperfusion ischaemia play a pathogenesis dementia development, but alternative hypotheses also emerging. Further fundamental studies will help determine mechanisms damage patients other age-related forms dementia. necessary effective treatment prevention.